IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis

X Li, H Zhang, F Yu, S Xie, T Wang, R Zhang, G Xu… - Genes & …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome arising from lipid
metabolic imbalance, with its prevalence increasing globally. In this study, we observed a …

[PDF][PDF] Hepatic interferon regulatory factor 6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing peroxisome proliferator‐activated receptor …

J Tong, CJ Han, JZ Zhang, WZ He, GJ Zhao… - …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and
growing unmet therapeutic need has inspired numerous studies in the field. Integrating the …

[PDF][PDF] Hepatic IRF2BP2 mitigates nonalcoholic fatty liver disease by directly repressing the transcription of ATF3

J Fang, YX Ji, P Zhang, L Cheng, Y Chen, J Chen… - …, 2020 - Wiley Online Library
Background and Aims Although knowledge regarding the pathogenesis of nonalcoholic fatty
liver disease (NAFLD) has profoundly grown in recent decades, the internal restrictive …

[PDF][PDF] Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

XA Wang, R Zhang, D Jiang, W Deng, S Zhang… - …, 2013 - Wiley Online Library
Obesity is a calorie‐excessive state associated with high risk of diabetes, atherosclerosis,
and certain types of tumors. Obesity may induce inflammation and insulin resistance (IR) …

Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway

Y He, W Yang, L Gan, S Liu, Q Ni, Y Bi, T Han… - Gastroenterologia y …, 2021 - Elsevier
Objective Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease.
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …

Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b

SJ Patel, N Liu, S Piaker, A Gulko… - Science translational …, 2022 - science.org
Inflammation has profound but poorly understood effects on metabolism, especially in the
context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic …

[PDF][PDF] Interferon regulatory factor 3 constrains IKKβ/NF‐κB signaling to alleviate hepatic steatosis and insulin resistance

XA Wang, R Zhang, ZG She, XF Zhang, DS Jiang… - …, 2014 - Wiley Online Library
Obesity and related metabolic diseases associated with chronic low‐grade inflammation
greatly compromise human health. Previous observations on the roles of interferon …

MiR-18 regulates lipid metabolism of non-alcoholic fatty liver disease via IGF1

H Yang, B Zhang, C Yu - Cellular and Molecular Biology, 2024 - cellmolbiol.org
We aimed to illustrate the regulatory effect of miR-18 on the onset of non-alcoholic fatty liver
disease (NAFLD). MiR-18 level in liver tissues collected from NAFLD patients and mice was …

Insulin‐like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non‐alcoholic fatty liver disease

H Yan, T Li, Y Wang, H Li, J Xu… - Clinical and experimental …, 2019 - Wiley Online Library
An association between increased insulin‐like growth factor binding protein‐7 (IGFBP 7)
expression and insulin resistance in metabolic diseases has been reported. However, the …

IRW prevents diet-induced non-alcoholic fatty liver disease by preserving mitochondrial content and enhancing hepatic fatty acid oxidation capacity

SC de Campos Zani, E Berg, X Jiang, A Knox… - 2023 - researchsquare.com
Non-alcoholic fatty liver disease (NAFLD) the hepatic manifestation of the metabolic
syndrome, remains without approved pharmacological treatment, with lifestyle modifications …