IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis
X Li, H Zhang, F Yu, S Xie, T Wang, R Zhang, G Xu… - Genes & …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome arising from lipid
metabolic imbalance, with its prevalence increasing globally. In this study, we observed a …
metabolic imbalance, with its prevalence increasing globally. In this study, we observed a …
[PDF][PDF] Hepatic interferon regulatory factor 6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing peroxisome proliferator‐activated receptor …
J Tong, CJ Han, JZ Zhang, WZ He, GJ Zhao… - …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and
growing unmet therapeutic need has inspired numerous studies in the field. Integrating the …
growing unmet therapeutic need has inspired numerous studies in the field. Integrating the …
[PDF][PDF] Hepatic IRF2BP2 mitigates nonalcoholic fatty liver disease by directly repressing the transcription of ATF3
J Fang, YX Ji, P Zhang, L Cheng, Y Chen, J Chen… - …, 2020 - Wiley Online Library
Background and Aims Although knowledge regarding the pathogenesis of nonalcoholic fatty
liver disease (NAFLD) has profoundly grown in recent decades, the internal restrictive …
liver disease (NAFLD) has profoundly grown in recent decades, the internal restrictive …
[PDF][PDF] Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice
Obesity is a calorie‐excessive state associated with high risk of diabetes, atherosclerosis,
and certain types of tumors. Obesity may induce inflammation and insulin resistance (IR) …
and certain types of tumors. Obesity may induce inflammation and insulin resistance (IR) …
Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway
Y He, W Yang, L Gan, S Liu, Q Ni, Y Bi, T Han… - Gastroenterologia y …, 2021 - Elsevier
Objective Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease.
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b
Inflammation has profound but poorly understood effects on metabolism, especially in the
context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic …
context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic …
[PDF][PDF] Interferon regulatory factor 3 constrains IKKβ/NF‐κB signaling to alleviate hepatic steatosis and insulin resistance
Obesity and related metabolic diseases associated with chronic low‐grade inflammation
greatly compromise human health. Previous observations on the roles of interferon …
greatly compromise human health. Previous observations on the roles of interferon …
MiR-18 regulates lipid metabolism of non-alcoholic fatty liver disease via IGF1
H Yang, B Zhang, C Yu - Cellular and Molecular Biology, 2024 - cellmolbiol.org
We aimed to illustrate the regulatory effect of miR-18 on the onset of non-alcoholic fatty liver
disease (NAFLD). MiR-18 level in liver tissues collected from NAFLD patients and mice was …
disease (NAFLD). MiR-18 level in liver tissues collected from NAFLD patients and mice was …
Insulin‐like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non‐alcoholic fatty liver disease
H Yan, T Li, Y Wang, H Li, J Xu… - Clinical and experimental …, 2019 - Wiley Online Library
An association between increased insulin‐like growth factor binding protein‐7 (IGFBP 7)
expression and insulin resistance in metabolic diseases has been reported. However, the …
expression and insulin resistance in metabolic diseases has been reported. However, the …
IRW prevents diet-induced non-alcoholic fatty liver disease by preserving mitochondrial content and enhancing hepatic fatty acid oxidation capacity
SC de Campos Zani, E Berg, X Jiang, A Knox… - 2023 - researchsquare.com
Non-alcoholic fatty liver disease (NAFLD) the hepatic manifestation of the metabolic
syndrome, remains without approved pharmacological treatment, with lifestyle modifications …
syndrome, remains without approved pharmacological treatment, with lifestyle modifications …