The volume and composition of a thin layer of liquid covering the airway surface defend the
lung from inhaled pathogens and debris. Airway epithelia secrete Cl–into the airway surface …

The airway epithelium contains ionocytes, a rare cell type with high expression of Forkhead
Box I1 (FOXI1) transcription factor and Cystic Fibrosis Transmembrane conductance …

Cystic fibrosis (CF) is caused by the loss of functional CFTR Cl− channels. However, it is not
understood how this defect disrupts salt and liquid movement in the airway or whether it …

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) Cl− channel, which mediates transepithelial Cl− transport in a variety of …

Two Cl− conductances have been described in the apical membrane of both human and
murine proximal airway epithelia that are thought to play predominant roles in airway …

Cystic fibrosis (CF) is caused by defects in an anion channel, the cystic fibrosis
transmembrane conductance regulator (CFTR). Recently, a new airway epithelial cell type …

Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …

The proper homeostasis of the airway surface liquid (ASL) depends on transepithelial ion
and fluid transport and is critically important for lung defence, and more specifically for …

Key points• The mechanisms of anion and fluid transport by airway submucosal glands are
not well understood and may differ from those in surface epithelium.• The Calu‐3 cell line is …

Human airway serous cells secrete antibiotic-rich fluid, but, in cystic fibrosis (CF), Cl−-
dependent fluid secretion is impaired by defects in CF transmembrane conductance …