[HTML][HTML] Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy

MK Jayasinghe, M Pirisinu, Y Yang, B Peng… - Theranostics, 2022 - ncbi.nlm.nih.gov
The advent of novel therapeutics in recent years has urged the need for a safe, non-
immunogenic drug delivery vector capable of delivering therapeutic payloads specifically to …

[HTML][HTML] Extracellular vesicle-based drug delivery systems for cancer treatment

S Walker, S Busatto, A Pham, M Tian, A Suh… - Theranostics, 2019 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play
important roles in many physiological and pathological processes. EVs enable intercellular …

Application of engineered extracellular vesicles for targeted tumor therapy

F Zhang, J Guo, Z Zhang, M Duan, G Wang… - Journal of biomedical …, 2022 - Springer
All cells, including prokaryotes and eukaryotes, could release extracellular vesicles (EVs).
EVs contain many cellular components, including RNA, and surface proteins, and are …

New approaches in extracellular vesicle engineering for improving the efficacy of anti-cancer therapies

MK Jayasinghe, M Tan, B Peng, Y Yang, G Sethi… - Seminars in Cancer …, 2021 - Elsevier
Cancer is a disease that evolves continuously with unpredictable outcomes. Although
conventional chemotherapy can display significant antitumor effects, the lack of specificity …

Engineered extracellular vesicles for cancer therapy

X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy

Y Tang, X Liu, M Sun, S Xiong, N Xiao, J Li, X He, J Xie - Pharmaceutics, 2023 - mdpi.com
Extracellular vesicles (EVs) are small, membrane-based vesicles released by cells that play
a critical role in various physiological and pathological processes. They act as vehicles for …

Extracellular vesicles as biological shuttles for targeted therapies

S Raimondo, G Giavaresi, A Lorico… - International journal of …, 2019 - mdpi.com
The development of effective nanosystems for drug delivery represents a key challenge for
the improvement of most current anticancer therapies. Recent progress in the understanding …

Engineering extracellular vesicles for cancer therapy: recent advances and challenges in clinical translation

S Li, J Xu, J Qian, X Gao - Biomaterials science, 2020 - pubs.rsc.org
Extracellular vesicles (EVs) are receiving increasing attention in recent years in the field of
cancer treatment. EVs contain specific contents closely related to their donor cells, such as …

Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems

M Lu, H Xing, Z Xun, T Yang, X Zhao, C Cai… - European Journal of …, 2018 - Elsevier
Extracellular vesicles (EVs) are membrane enclosed vesicles that are shed by almost all cell
types, and play a fundamental role in cell-to-cell communication. The discovery that EVs are …

Strategies for engineering of extracellular vesicles

AA Danilushkina, CC Emene, NA Barlev… - International journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released by cells into the extracellular
space. EVs mediate cell-to-cell communication through local and systemic transportation of …