Modulation of hippocampal excitability and seizures by galanin

AM Mazarati, JG Hohmann, A Bacon, H Liu… - Journal of …, 2000 - Soc Neuroscience
Previous studies have shown that the expression of the neuropeptide galanin in the
hippocampus is altered by seizures and that exogenous administration of galanin into the …

Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure‐induced neurogenesis in the dentate gyrus

A Mazarati, X Lu, K Kilk, Ü Langel… - European Journal of …, 2004 - Wiley Online Library
The neuropeptide galanin has been implicated in inhibiting seizures and protecting
hippocampal neurons from excitotoxic injury. In the hippocampus galanin acts through two …

Book Review: Galanin: An Endogenous Anticonvulsant?

A Mazarati, ülo Langel, T Bartfai - The neuroscientist, 2001 - journals.sagepub.com
Galanin is a neuroendocrine peptide involved in the regulation of feeding, pain, sexual
behavior, learning, and memory. The recent discovery, that galanin antagonized excitatory …

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

M Kokaia, K Holmberg… - Proceedings of the …, 2001 - National Acad Sciences
The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and
hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We …

Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus

AM Mazarati, H Liu, U Soomets, R Sankar… - Journal of …, 1998 - Soc Neuroscience
We examined the role of hippocampal galanin in an animal model of status epilepticus (SE).
Control rats showed abundant galanin-immunoreactive (Gal-IR) fibers in the dentate hilus …

Galanin and galanin receptors in epilepsy

AM Mazarati - Neuropeptides, 2004 - Elsevier
The shift in the balance between the inhibition and the excitation in favor of the latter is a
major mechanism of the evolvement of epileptic seizures. On the neurotransmitter level two …

Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors

A Mazarati, X Lu - Neuropeptides, 2005 - Elsevier
It has been well established that galanin is a potent endogenous anticonvulsant peptide.
However, the role of galanin receptor subtypes in mediating anticonvulsant effects of the …

Recombinant AAV‐mediated expression of galanin in rat hippocampus suppresses seizure development

EJD Lin, C Richichi, D Young, K Baer… - European Journal of …, 2003 - Wiley Online Library
Abstract Galanin, a 29‐or 30‐amino acid neuropeptide, has been implicated in the
modulation of seizures. In this study, we constructed a recombinant adeno‐associated viral …

Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice

A Mazarati, X Lu, S Shinmei, H Badie-Mahdavi… - Neuroscience, 2004 - Elsevier
The neuropeptide galanin exhibits anticonvulsant effects in experimental epilepsy. Two
galanin receptor subtypes, GalR1 and GalR2, are present in the brain. We examined the …

Galanin–25 years with a multitalented neuropeptide: Galanin and epilepsy

JT Lerner, R Sankar, AM Mazarati - Cellular and Molecular Life Sciences, 2008 - Springer
Neuroanatomical localization and physiological properties of galanin suggest that the
peptide may be involved in the regulation of seizures. Indeed, administration of galanin …