Modulation of hippocampal excitability and seizures by galanin
AM Mazarati, JG Hohmann, A Bacon, H Liu… - Journal of …, 2000 - Soc Neuroscience
Previous studies have shown that the expression of the neuropeptide galanin in the
hippocampus is altered by seizures and that exogenous administration of galanin into the …
hippocampus is altered by seizures and that exogenous administration of galanin into the …
Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure‐induced neurogenesis in the dentate gyrus
The neuropeptide galanin has been implicated in inhibiting seizures and protecting
hippocampal neurons from excitotoxic injury. In the hippocampus galanin acts through two …
hippocampal neurons from excitotoxic injury. In the hippocampus galanin acts through two …
Book Review: Galanin: An Endogenous Anticonvulsant?
A Mazarati, ülo Langel, T Bartfai - The neuroscientist, 2001 - journals.sagepub.com
Galanin is a neuroendocrine peptide involved in the regulation of feeding, pain, sexual
behavior, learning, and memory. The recent discovery, that galanin antagonized excitatory …
behavior, learning, and memory. The recent discovery, that galanin antagonized excitatory …
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
M Kokaia, K Holmberg… - Proceedings of the …, 2001 - National Acad Sciences
The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and
hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We …
hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We …
Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus
We examined the role of hippocampal galanin in an animal model of status epilepticus (SE).
Control rats showed abundant galanin-immunoreactive (Gal-IR) fibers in the dentate hilus …
Control rats showed abundant galanin-immunoreactive (Gal-IR) fibers in the dentate hilus …
Galanin and galanin receptors in epilepsy
AM Mazarati - Neuropeptides, 2004 - Elsevier
The shift in the balance between the inhibition and the excitation in favor of the latter is a
major mechanism of the evolvement of epileptic seizures. On the neurotransmitter level two …
major mechanism of the evolvement of epileptic seizures. On the neurotransmitter level two …
Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors
A Mazarati, X Lu - Neuropeptides, 2005 - Elsevier
It has been well established that galanin is a potent endogenous anticonvulsant peptide.
However, the role of galanin receptor subtypes in mediating anticonvulsant effects of the …
However, the role of galanin receptor subtypes in mediating anticonvulsant effects of the …
Recombinant AAV‐mediated expression of galanin in rat hippocampus suppresses seizure development
Abstract Galanin, a 29‐or 30‐amino acid neuropeptide, has been implicated in the
modulation of seizures. In this study, we constructed a recombinant adeno‐associated viral …
modulation of seizures. In this study, we constructed a recombinant adeno‐associated viral …
Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice
A Mazarati, X Lu, S Shinmei, H Badie-Mahdavi… - Neuroscience, 2004 - Elsevier
The neuropeptide galanin exhibits anticonvulsant effects in experimental epilepsy. Two
galanin receptor subtypes, GalR1 and GalR2, are present in the brain. We examined the …
galanin receptor subtypes, GalR1 and GalR2, are present in the brain. We examined the …
Galanin–25 years with a multitalented neuropeptide: Galanin and epilepsy
JT Lerner, R Sankar, AM Mazarati - Cellular and Molecular Life Sciences, 2008 - Springer
Neuroanatomical localization and physiological properties of galanin suggest that the
peptide may be involved in the regulation of seizures. Indeed, administration of galanin …
peptide may be involved in the regulation of seizures. Indeed, administration of galanin …