The regulation of whole-body homeostasis by the skeleton is mediated by its capacity to
secrete endocrine signaling molecules. Although bone-derived hormones confer several …

Our knowledge of whole organism physiology has greatly advanced in the past decades
through mouse genetics. In particular, genetic studies have revealed that most organs …

The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …

Bone has always been regarded as a merely structural tissue, a “hard” scaffold protecting all
of its “soft” fellows, while they did the rest of the work. In the last few decades this concept …

Résumé Usually vertebrate physiology is studied within the confined limits of a given organ,
if not cell type. This approach has progressively changed with the emergence of mouse …

Landmark advances in skeletal biology have arisen mainly from the identification of disease-
causing mutations and the advent of rapid and selective gene-targeting technologies to …

In the last two decades, bone tissue has been recognized as an endocrine organ able to
regulate the physiology of the whole body. Indeed, from the ancient “vision” of the skeleton …

The maintenance of our physiological functions and their adaptive response to
environmental changes depend on precise crosstalk between organs. Recent advances in …

Recent developments in endocrinology, made possible by the combination of mouse
genetics, integrative physiology and clinical observations have resulted in rapid and …

The regulation of mineral homeostasis involves the three mineralotropic hormones PTH,
FGF23 and 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3). Early research efforts focused on …