[HTML][HTML] Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions
Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which the lungs become
irreversibly scarred, leading to declining lung function. As currently available drugs do not …
irreversibly scarred, leading to declining lung function. As currently available drugs do not …
Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls
The currently accepted approach to treatment of idiopathic pulmonary fibrosis (IPF) is based
on the assumption that it is a chronic inflammatory disease, and most available …
on the assumption that it is a chronic inflammatory disease, and most available …
Emerging therapeutic interventions for idiopathic pulmonary fibrosis
Introduction: Idiopathic pulmonary fibrosis (IPF) is a devastating and relentlessly progressive
lung disorder. Previously, it was thought to be a chronic inflammatory disease; however, it is …
lung disorder. Previously, it was thought to be a chronic inflammatory disease; however, it is …
Cell therapy for idiopathic pulmonary fibrosis: rationale and progress to date
P Ntolios, P Steiropoulos, G Karpathiou, S Anevlavis… - BioDrugs, 2020 - Springer
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by progressive
lung scarring due to unknown injurious stimuli ultimately leading to respiratory failure …
lung scarring due to unknown injurious stimuli ultimately leading to respiratory failure …
Developmental pathways in the pathogenesis of lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
Investigational approaches to therapies for idiopathic pulmonary fibrosis
RH Gomer, ML Lupher Jr - Expert opinion on investigational drugs, 2010 - Taylor & Francis
Importance of the field: In fibrosing diseases, scar tissue begins to replace normal tissue,
causing tissue dysfunction. For instance, in lung fibrosis, foci of what resembles scar tissue …
causing tissue dysfunction. For instance, in lung fibrosis, foci of what resembles scar tissue …
Shedding light on developmental drugs for idiopathic pulmonary fibrosis
P Spagnolo, F Bonella, CJ Ryerson… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is an age-related disease of unknown cause.
The disease is characterized by relentless scarring of the lung parenchyma resulting in …
The disease is characterized by relentless scarring of the lung parenchyma resulting in …
New therapeutics based on emerging concepts in pulmonary fibrosis
Introduction: Fibrosis is an irreversible pathological endpoint in many chronic diseases,
including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often …
including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often …
Development of novel agents for idiopathic pulmonary fibrosis: progress in target selection and clinical trial design
TG O'Riordan, V Smith, G Raghu - Chest, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease. Until recently, the standard
therapy for this disease has been essentially supportive, with the exception of a minority of …
therapy for this disease has been essentially supportive, with the exception of a minority of …
Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis
M Gharaee-Kermani, SH Phan - Current pharmaceutical design, 2005 - ingentaconnect.com
Pulmonary fibrosis is characterized by lung inflammation and abnormal tissue repair,
resulting in the replacement of normal functional tissue with an abnormal accumulation of …
resulting in the replacement of normal functional tissue with an abnormal accumulation of …