We present a novel immunotherapeutic strategy using a human B7-DC cross-linking Ab that
prevents lung inflammation, airway obstruction, and hyperreactivity to allergen in a mouse …

BACKGROUND: Allergic asthma is an increasing clinical problem that might be addressed
with immunologically based interventions. A novel human antibody that activates human …

B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that
treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in …

Previous studies have shown that the pan CD28/cytotoxic T lymphocyte antigen (CTL) A-4
antagonist CTLA4 immunoglobulin (Ig) inhibits eosinophilic airway inflammation in …

Abstract B7-H1 (PD-L1) and B7-DC (PD-L2) are the ligands for programmed death-1 (PD-1),
which is a member of the CD28/CTLA-4 family and has been implicated in peripheral …

Activated T cells have been implicated in chronic rhinosinusitis (CRS) and asthma and
physically interact with epithelial cells in the airways. We now report that human airway …

Background B7 molecules play a key role in regulating allergen-induced T cell activation in
asthma, which may occur through T cell recruitment and T helper cell differentiation on …

Antigen-specific T-cell activation requires the engagement of the T-cell receptor (TCR) with
antigen as well as the engagement of appropriate costimulatory molecules. One of the most …

B cells have been described as having the capacity to regulate cellular immune responses
and suppress inflammatory processes. One such regulatory B‐cell population is defined as …

The role of complement in the development of maladaptive immunity in experimental allergic
asthma is unclear. In this study, we show that C3a receptor (C3aR)-deficient mice are …