During embryonic development, groups of cells become assigned to different fates (to form
different tissues and organs) in response to signals from a small set of specialised signalling …

Neural induction, ie definition of the neural domain from the ectoderm, is a fundamental topic
that has fascinated developmental biologists for years. The concept was first proposed by …

During early vertebrate development, signals from a special region of the embryo, the
organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned …

Neural induction constitutes the initial step in the generation of the vertebrate nervous
system. In attempting to understand the principles that underlie this process, two key issues …

Neural induction marks the beginning of vertebrate nervous system formation, consisting of
an interaction between the organizer, which emits inducing signals, and the ectoderm, which …

Publisher Summary Despite the recent studies on avian and mammalian embryos, much of
the knowledge on neural induction is still based on experimentation with amphibian …

Until recently, almost everything known about the molecular controls of early neural
development came from studies in amphibians. It is now possible to misexpress factors in …

Temporal changes in progenitor cell responses to extrinsic signals play an important role in
development, but little is known about the mechanisms that determine how these changes …

A surprisingly small number of signalling pathways are used reiteratively during neural
development, eliciting very different responses depending on the cellular context. Thus, the …

The problem of “primary embryonic induction” was one of the first areas of developmental
biology to become “molecularized.” What had been seen as an intractable series of …