The chick embryo is a valuable tool in the study of early embryonic development. Its
transparency, accessibility and ease of manipulation, make it an ideal tool for studying the …

Previous studies on neural induction have identified regionally localized inducing activities,
signaling molecules, potential competence factors and various other features of this …

Bone morphogenetic protein (BMP) signaling plays a crucial role in maintaining the
pluripotency of mouse embryonic stem cells (ESCs) and has negative effects on ESC neural …

▪ Abstract The formation of the vertebrate nervous system is initiated at gastrula stages of
development, when signals from a specialized cluster of cells (the organizer) trigger neural …

Neural progenitors undergo temporal fate transition to generate diversified neurons in
stereotyped sequence during development. However, the molecular machineries driving …

Over the past decade, several molecules have been identified that influence neural cell fate
in vertebrate embryos during gastrulation. The first neural inducers studied were proteins …

Spemann's organizer experiment in 1924 suggested that neural tissue is induced from
prospective epidermal tissue by a secreted factor1. Since then, neural induction has been a …

Neural induction is a very early stage in development of the nervous system during which a
portion of one of the primary germ layers, the ectoderm, is specified into neuroectoderm and …

How does the vertebrate embryo make a nervous system? This complex question has been
at the center of developmental biology for many years. The earliest step in this process–the …