Superantigens combine with MHC class-II molecules to form the ligands that stimulate T
cells via the Vβ element of the T-cell receptor. Two groups of superantigens have been …

Superantigens are powerful microbial toxins that activate the immune system by binding to
class II major histocompatibility complex and T-cell receptor molecules. They cause a …

Superantigens are a class of immunostimulatory molecules produced by bacterla and
viruses. Their potent immune effects are due to their unique ability to bind to the major …

The current model of superantigen activity assumes that the superantigen simultaneously
binds to both the MHC molecule on the presenting cell and the V~ element of the TCR …

In the face of the unique diversity and plasticity of the immune system pathogenic organisms
have developed multiple mechanisms in adaptation to their hosts, including the expression …

Superantlgens, Including the staphylococcal enterotoxins and the minor lymphocyte
stimulatory antigens, are highly potent lmmunostlmulatory molecules, capable of activating …

Superantigens are highly potent immune stimulators with a unique ability to interact
simultaneously with MHC class II molecules and T cell receptors, forming a trimolecular …

Superantigens stimulate powerful T-cell responses that can have marked effects in vivo,
sometimes leading to shock or even death. The demonstration that strong T-cell responses …

Superantigen-MHC complexes are known to stimulate T cells primarily via the Vp element of
the T cell receptor. In this paper we identify a number of amino acid residues that define the …

Superantigens are able to stimulate T lymphocyte populations expressing T cell antigen
receptors (TCR) belonging to particular Vβ families. Moreover, the presence of these …