Key points Compared with sham rats, rats a week after acute lung injury (ALI) express more
pro‐inflammatory cytokines in their brainstem respiratory control nuclei, exhibit a higher …

Acute lung injury evokes a pulmonary inflammatory response and changes in the breathing
pattern. The inflammatory response has a centrally mediated component which depends on …

Introduction: Biometrics of common physiologic signals can reflect health status. We have
developed analytics to measure the predictability of ventilatory pattern variability (VPV …

Neurological dysfunction and delirium may affect up to 80% of patients in the ICU but are
frequently underrecognized and underdiagnosed (1). Neurocognitive impairment and even …

In infants, respiratory infection elicits tachypnea. To begin to evaluate the role of brainstem
cytokine expression in modulation of breathing pattern changes, we compared the pattern …

The complexity of respiratory dynamics is decreased, in association with disease severity, in
patients with asthma. However, the pathophysiological basis of decreased complexity of …

Introduction The acute respiratory distress syndrome is not only associated with a high
mortality, but also goes along with cognitive impairment in survivors. The cause for this …

Augmented breaths (ABs), or sighs, are airway protective reflexes and part of the normal
repertoire of respiratory behaviors. ABs consist of two phases, where phase I volume and …

Breathing is a vital homeostatic behavior and must be precisely regulated throughout life.
Clinical conditions commonly associated with inflammation, undermine respiratory function …

The pathways for peripheral-to-central immune communication (P→ C I-comm) following
sterile lung injury (SLI) are unknown. SLI evokes systemic and central inflammation, which …