Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of
the central nervous system (CNS). Here, we show that adult peripheral nerve is a more …

Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the
remarkable ability of peripheral nerves to regenerate following injury. However, the …

Repair in the peripheral nervous system (PNS) depends upon the plasticity of the
myelinating cells, Schwann cells, and their ability to dedifferentiate, direct axonal regrowth …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Peripheral innervation plays an important role in regulating tissue repair and regeneration.
Here we provide evidence that injured peripheral nerves provide a reservoir of …

Rodent models of nerve injury have increased our understanding of peripheral nerve
regeneration, but clinical applications have been scarce, partly because such models do not …

Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of
the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but …