Ail is shown to be an essential virulence factor with multiple roles in pathogenesis. The
recent adaptation of Yersinia pestis to high virulence, which included genomic reduction to …

Yersinia pestis, a Gram-negative bacterium, is the etiologic agent of plague. A hallmark of Y.
pestis infection is the organism's ability to rapidly disseminate through an animal host. Y …

Yersinia pestis is one of the most virulent bacteria identified. It is the causative agent of
plague—a systemic disease that has claimed millions of human lives throughout history. Y …

Ail, a multifunctional outer membrane protein of Yersinia pestis, confers cell binding, Yop
delivery and serum resistance activities. Resistance to complement proteins in serum is …

Yersinia pestis, the causative agent of plague, must survive in blood in order to cause
disease and to be transmitted from host to host by fleas. Members of the Ail/Lom family of …

Although adhesion to host cells is a critical step in the delivery of cytotoxic Yop proteins by
Yersinia pestis, the mechanism has not been defined. To identify adhesins critical for Yop …

The outer membrane is a key virulence determinant of gram‐negative bacteria. In Yersinia
pestis, the deadly agent that causes plague, the protein Ail and lipopolysaccharide (LPS) 6 …

Yersinia pestis, the causative agent of plague, binds host cells to deliver cytotoxic Yop
proteins into the cytoplasm that prevent phagocytosis and generation of proinflammatory …

Yersinia pestis, the causative agent of plague, is one of the most virulent microorganisms
known. The outer membrane protein X (OmpX) in Y. pestis KIM is required for efficient …

The Yersinia pestis adhesin Ail mediates host cell binding and facilitates delivery of cytotoxic
Yop proteins. Ail from Y. pestis and Y. pseudotuberculosis is identical except for one or two …