ABSTRACT Synthesis of Escherichia coli LpxL, which transfers a secondary laurate chain to
the 2′ position of lipid A, in Yersinia pestis produced bisphosphoryl hexa-acylated lipid A at …

Yersinia pestis undergoes an obligate flea–rodent–flea enzootic life cycle. The rapidly fatal
properties of Y. pestis are responsible for the organism's sustained survival in natural plague …

Deletion mutants in the lpxM gene in two Yersinia pestis strains, the live Russian vaccine
strain EV NIIEG and a fully virulent strain, 231, synthesise a less toxic penta-acylated …

Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y.
pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll …

Deletion of the murein (Braun) lipoprotein gene, lpp, attenuates the Yersinia pestis CO92
strain in mouse models of bubonic and pneumonic plague. In this report, we characterized …

Important pathogens in the genus Yersinia include the plague bacillus Yersinia pestis and
two enteropathogenic species, Yersinia pseudotuberculosis and Yersinia enterocolitica. A …

Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of
bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar …

At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes
lipopolysaccharide (LPS)–lipid A with poor Toll-like receptor 4 (TLR4)–stimulating activity …

Vaccinating with live, conditionally attenuated, pigmentation (Pgm)-deficient Yersinia pestis
primes T cells that protect mice against pneumonic plague. However, Pgm-deficient strains …

Isogenic Y. pestis strains with a single mutation in 14 genes of lipopolysaccharide (LPS)
biosynthetic pathways were constructed. Using high-resolution electrospray ionization mass …