To implant in the uterus, the mammalian embryo first specifies two cell lineages: the
pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms …

During post-implantation development of the mouse embryo, descendants of the inner cell
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …

Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …

Cell growth, an increase in mass and size, is a highly regulated cellular event. The
Akt/mTOR (mammalian target of rapamycin) signalling pathway has a central role in the …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional …

Paternal and maternal epigenomes undergo marked changes after fertilization. Recent
epigenomic studies have revealed the unusual chromatin landscapes that are present in …

It has been reported previously that keratin 8 (K8)‐deficient mice of one strain die from a
liver defect at around E12. 5, while those of another strain suffer from colorectal hyperplasia …

During pre-implantation development, the mammalian embryo self-organizes into the
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …

Implantation of the blastocyst is a developmental milestone in mammalian embryonic
development. At this time, a coordinated program of lineage diversification, cell-fate …