New methods for the genome-wide analysis of chromatin are providing insight into its roles
in development and their underlying mechanisms. Current studies indicate that chromatin is …

Remodelling its shape, or morphogenesis, is a fundamental property of living tissue. It
underlies much of embryonic development and numerous pathologies. Convergent …

The cytoskeleton—comprising actin filaments, microtubules and intermediate filaments—
serves instructive roles in regulating cell function and behaviour during development …

The reprogramming of human somatic cells to primed or naive induced pluripotent stem
cells recapitulates the stages of early embryonic development,,,,–. The molecular …

An open chromatin largely devoid of heterochromatin is a hallmark of stem cells. It remains
unknown whether an open chromatin is necessary for the differentiation potential of stem …

Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in
vitro,,,–, but their developmental potential is substantially extended by interactions with …

Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …

The development of complex stratified epithelial barriers in mammals is initiated from single-
layered epithelia. How stratification is initiated and fueled are still open questions. Previous …

Intercellular communication is essential to coordinate the behaviour of individual cells
during organismal development. The preimplantation mammalian embryo is a paradigm of …

Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human
embryonic stem cells (hESCs) can generate the three germ layers in culture; however …