This report integrates knowledge of in situ macromolecular structures and synaptic protein
biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking …

Active zone material is an organelle that is common to active zones along the presynaptic
membrane of chemical synapses. Electron tomography on active zones at frog …

Synaptic vesicles dock at active zones on the presynaptic plasma membrane of a neuron's
axon terminals as a precondition for fusing with the membrane and releasing their …

The docking of synaptic vesicles on the presynaptic membrane and their priming for fusion
with it to mediate synaptic transmission of nerve impulses typically occur at structurally …

The active zones of axon terminals are where the initial events in synaptic transmission
occur. They are characterized by dense aggregates of macromolecules attached to the …

Nerve terminals of the central nervous system (CNS) contain specialized release sites for
synaptic vesicles, referred to as active zones. They are characterized by electron‐dense …

The docking of synaptic vesicles at active zones on the presynaptic plasma membrane of
axon terminals is essential for their fusion with the membrane and exocytosis of their …

Active zones are highly specialized sites for release of neurotransmitter from presynaptic
nerve terminals. The architecture of the active zone is exquisitely designed to facilitate the …

The release of neurotransmitters from synaptic vesicles exocytosing at presynaptic nerve
terminals is a critical event in the initiation of synaptic transmission. This event occurs at …

Highlights•The molecular components of synapses are segregated into distinct functional
domains.•Distinct synaptic subdomains can be observed at the macro and micro scale …