Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice

YD Zhang, DD Shi, BB Liao, Y Li, S Zhang, J Gao… - Molecular …, 2024 - nature.com
Emerging evidence suggests that the gut microbiota is closely related to psychiatric
disorders. However, little is known about the role of the gut microbiota in the development of …

Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions

EA Troyer, JN Kohn, G Ecklu-Mensah, G Aleti… - Neuroscience & …, 2021 - Elsevier
Obsessive-compulsive disorder (OCD) is disabling and often treatment-refractory. Host
immunity and gut microbiota have bidirectional communication with each other and with the …

An update on the relationship between the gut microbiome and obsessive-compulsive disorder

J Turna, B Patterson, M Van Ameringen - Psychiatric Annals, 2017 - journals.healio.com
The gut microbiome, the collection of microbes and their genetic material in the human
gastrointestinal tract, has recently become a topic of interest in psychiatry. To date, animal …

“What's bugging the gut in OCD?” A review of the gut microbiome in obsessive–compulsive disorder

J Turna, K Grosman Kaplan, R Anglin… - Depression and …, 2016 - Wiley Online Library
The gut microbiome has become a topic of major interest as of late, with a new focus
specifically on psychiatric disorders. Recent studies have revealed that variations in the …

Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder

L Domènech, J Willis, M Alemany-Navarro, M Morell… - Scientific Reports, 2022 - nature.com
Although the etiology of obsessive–compulsive disorder (OCD) is largely unknown, it is
accepted that OCD is a complex disorder. There is a known bi-directional interaction …

Microbial reprogramming in obsessive–compulsive disorders: a review of gut–brain communication and emerging evidence

G Bendriss, R MacDonald, C McVeigh - International Journal of …, 2023 - mdpi.com
Obsessive–compulsive disorder (OCD) is a debilitating mental health disorder characterized
by intrusive thoughts (obsessions) and repetitive behaviors (compulsions). Dysbiosis, an …

Gut microbiome in obsessive compulsive disorder: potential of probiotics as an adjuvant therapy

GYE Kong, V Letchumanan, LTH Tan… - Progress In Microbes …, 2022 - research.monash.edu
The gut-brain axis concept has become an exciting area of research in psychiatry.
Gastrointestinal inflammation and gut microbiome dysbiosis have been associated with …

Implication of microbiota gut-brain axis in the manifestation of obsessive-compulsive disorder: Preclinical and clinical evidence

SR Kamble, MP Dandekar - European Journal of Pharmacology, 2023 - Elsevier
Recent research has highlighted the key role of gut microbiota in the development of
psychiatric disorders. The adverse impact of stress, anxiety, and depression has been well …

Longitudinal study of gut microbiome in obsessive–compulsive disorder

LL Chen, A Abbaspour, K Aspvall, C Rück… - Brain and …, 2023 - Wiley Online Library
Introduction Patients with obsessive–compulsive disorder (OCD) often have limited
exposure to a diverse environment and perform repetitive compulsions such as excessive …

The gut microbiome and inflammation in obsessive‐compulsive disorder patients compared to age‐and sex‐matched controls: a pilot study

J Turna, K Grosman Kaplan, R Anglin… - Acta Psychiatrica …, 2020 - Wiley Online Library
Objective To compare the gut microbiome profile (by way of taxon analysis and indices of β‐
and α‐diversity) and inflammatory markers (C‐reactive protein [CRP], interleukin‐6 [IL‐6] …