Super-enhancers (SEs) comprise large clusters of enhancers, which are co-occupied by
multiple lineage-specific and master transcription factors, and play pivotal roles in regulating …

LncRNAs have recently emerged as new and fundamental transcriptional and post-
transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs …

Background: Long non-coding RNAs (lncRNAs) constitute an important component of the
regulatory apparatus that controls stem cell pluripotency. However, the specific mechanisms …

The power of embryonic stem cells (ESCs) lies in their ability to self-renew and differentiate.
Behind these two unique capabilities is a fine-tuned molecular network that shapes the …

Long noncoding (lnc) RNAs have recently emerged as key regulators of gene expression.
Here, we performed high-depth poly (A)+ RNA sequencing across multiple clonal …

Abstract Background Super-enhancer RNAs (seRNAs) are a kind of noncoding RNA
transcribed from super-enhancer regions. The regulation mechanism and functional role of …

Long noncoding RNAs (lncRNAs) have emerged as vital regulators of gene expression
during embryonic stem cell (ESC) self-renewal and differentiation. Here, we systemically …

Divergent lncRNAs that are transcribed in the opposite direction to nearby protein-coding
genes comprise a significant proportion (∼ 20%) of total lncRNAs in mammalian genomes …

Recent evidence suggests that lncRNAs play an integral regulatory role in numerous
functions, including determination of cellular identity. We determined global expression …

Long noncoding RNAs (lncRNAs) have been implicated in diverse biological processes,
including embryonic stem cell (ESC) maintenance. However, their functional mechanisms …