Addiction is a chronic, relapsing disorder characterised by the use of a substance or act to
the point of compulsion. There are a number of medical treatments available for the …

There has been increasing interest in the ability of neuropeptides involved in feeding to
modulate circuits important for responses to drugs of abuse. A number of peptides with …

Galanin and its receptors are expressed in brain areas associated with opiate reinforcement
and withdrawal. An emerging body of data suggests that galanin can attenuate the …

There has been increasing interest in the ability of neuropeptides involved in feeding to
modulate circuits important for responses to drugs of abuse. A number of peptides with …

The mechanisms underlying responses to drugs of abuse have been widely investigated;
however, less is known about pathways normally protective against the development of drug …

Much research has focused on pathways leading to opiate addiction. Pathways opposing
addiction are more difficult to study but may be critical in developing interventions to combat …

The neuropeptide, galanin, is widely expressed in the central and peripheral nervous
systems and is involved in a range of different functions including nociception …

Rationale The neuropeptide galanin has been shown to modulate opiate dependence and
withdrawal. These effects could be mediated via activation of one or more of the three …

Galanin is a neuropeptide synthesized in many neuronal types including brainstem
norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons …

The neuropeptide galanin is reported to attenuate opioid withdrawal symptoms, potentially
by reducing neuronal hyperactivity in the noradrenergic locus coeruleus (LC) via galanin …