HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–
25% of the total cases. It is characterized by aggressive behavior and treatment resistance …

pH-responsive dual-loaded nanoplatforms based on polyamidoamine dendrimer with a
hydroxyl-terminated surface (PAMAM–OH), generations 3, 4, and 5 (G3, G4, and G5 …

Polyamidoamine (PAMAM) dendrimers are cationic branch-like macromolecules that may
serve as drug delivery systems for gene-based therapies such as RNA interference. For their …

To overcome the obstacle of anti-cancer therapy significant attention has been drawn for
improving drug delivery system. Since recent past, different approaches were applied using …

Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …

In the present study, cationic generation 5 polyamido amine (G5 PAMAM) dendrimers were
hydrophobically modified by grafting the surface with lipid-like myristic acid (My) tails to …

The clinical application of methylglyoxal (MG, a normal human metabolite) for cancer
therapy is limited by its facile enzymatic degradation. The present investigation was aimed at …

Background Breast cancer is the second leading cause of cancer death worldwide.
Nanotechnology approaches can overcome the side effects of chemotherapy as well as …

In this study, we investigated the effect of amine-and hydroxyl-terminated Generation 2 and
3 (G2 and G3) poly (amidoamine)(PAMAM) dendrimers on the viability and induction of …

Tumor cells with stem cell properties are considered to play major roles in promoting the
development and malignant behavior of aggressive cancers. Therapeutic strategies that …