[HTML][HTML] Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
H Kheraldine, I Gupta, H Alhussain, A Jabeen… - Computational and …, 2021 - Elsevier
HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–
25% of the total cases. It is characterized by aggressive behavior and treatment resistance …
25% of the total cases. It is characterized by aggressive behavior and treatment resistance …
Peganum harmala Alkaloids and Tannic Acid Encapsulated in PAMAM Dendrimers: Improved Anticancer Activities as Compared to Doxorubicin
HMES Azzazy, AM Sawy, A Abdelnaser… - ACS Applied Polymer …, 2022 - ACS Publications
pH-responsive dual-loaded nanoplatforms based on polyamidoamine dendrimer with a
hydroxyl-terminated surface (PAMAM–OH), generations 3, 4, and 5 (G3, G4, and G5 …
hydroxyl-terminated surface (PAMAM–OH), generations 3, 4, and 5 (G3, G4, and G5 …
On the nanotoxicity of PAMAM dendrimers: Superfect® stimulates the EGFR–ERK1/2 signal transduction pathway via an oxidative stress-dependent mechanism in …
S Akhtar, B Chandrasekhar, S Attur, MHM Yousif… - International journal of …, 2013 - Elsevier
Polyamidoamine (PAMAM) dendrimers are cationic branch-like macromolecules that may
serve as drug delivery systems for gene-based therapies such as RNA interference. For their …
serve as drug delivery systems for gene-based therapies such as RNA interference. For their …
Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human …
K Priyadarshi, K Shirsath, NB Waghela… - Journal of …, 2021 - Taylor & Francis
To overcome the obstacle of anti-cancer therapy significant attention has been drawn for
improving drug delivery system. Since recent past, different approaches were applied using …
improving drug delivery system. Since recent past, different approaches were applied using …
PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …
Biological activity of dendrimer–methylglyoxal complexes for improved therapeutic efficacy against malignant cells
The clinical application of methylglyoxal (MG, a normal human metabolite) for cancer
therapy is limited by its facile enzymatic degradation. The present investigation was aimed at …
therapy is limited by its facile enzymatic degradation. The present investigation was aimed at …
Hydrophobic myristic acid modified PAMAM dendrimers augment the delivery of tamoxifen to breast cancer cells
I Matai, P Gopinath - RSC advances, 2016 - pubs.rsc.org
In the present study, cationic generation 5 polyamido amine (G5 PAMAM) dendrimers were
hydrophobically modified by grafting the surface with lipid-like myristic acid (My) tails to …
hydrophobically modified by grafting the surface with lipid-like myristic acid (My) tails to …
In vitro and in vivo uptake studies of PAMAM G4. 5 dendrimers in breast cancer
N Oddone, N Lecot, M Fernández… - Journal of …, 2016 - Springer
Background Breast cancer is the second leading cause of cancer death worldwide.
Nanotechnology approaches can overcome the side effects of chemotherapy as well as …
Nanotechnology approaches can overcome the side effects of chemotherapy as well as …
In vitro validation of the therapeutic potential of dendrimer-based nanoformulations against tumor stem cells
N Knauer, V Arkhipova, G Li, M Hewera… - International Journal of …, 2022 - mdpi.com
Tumor cells with stem cell properties are considered to play major roles in promoting the
development and malignant behavior of aggressive cancers. Therapeutic strategies that …
development and malignant behavior of aggressive cancers. Therapeutic strategies that …
Silencing of HMGA2 by siRNA loaded methotrexate functionalized polyamidoamine dendrimer for human breast cancer cell therapy
The transcription factor high mobility group protein A2 (HMGA2) plays an important role in
the pathogenesis of some cancers including breast cancer. Polyamidoamine dendrimer …
the pathogenesis of some cancers including breast cancer. Polyamidoamine dendrimer …