Oncogenic microRNA (miRNA), especially miRNA-21 upregulation in triple-negative breast
cancer (TNBC), suggests a new class of therapeutic targets. In this study, we aimed to create …

According to the cancer stem cell (CSC) theory, a small subset of cells with stem cell-like
characteristics is responsible for tumor initiation, progression, and recurrence. CD44+/CD24 …

Triple negative breast cancer (TNBC) presents a significant global health concern due to its
aggressive nature, high mortality rate and limited treatment options, highlighting the urgent …

Abstract P-glycoprotein (P-gp) associated multidrug resistance (MDR) represents a major
failure in cancer treatment. The overexpression of P-gp is responsible for ATP-dependent …

Dendrimers represents a highly branched three-dimensional structure that provides a high
degree of surface functionality and versatility. PAMAM dendrimers are used as well-defined …

Currently, in clinics, breast cancer is treated with free chemotherapeutic drugs, as a result
there is not much therapeutic effect in treated models, leading to substantial systemic …

Due to their unique structure, poly (amidoamine)(PAMAM) dendrimers have been widely
used in medical applications. However, PAMAM dendrimers bearing amino terminals show …

Characterization of dendrimers as potential therapeutics or drug carriers is complete only
when toxicity is assessed. There are numerous studies on the influence of surface …

Breast cancer is the most frequent malignancy affecting women, yet current therapeutic
strategies remain ineffective for patients with late‐stage or metastatic disease. Here an …

Breast cancer is the most common malignancy in women. Although personalized or
targeting molecular cancer therapy is more popular up to now, the cytotoxicity chemotherapy …