Characterization of dendrimers as potential therapeutics or drug carriers is complete only
when toxicity is assessed. There are numerous studies on the influence of surface …

Abstract P-glycoprotein (P-gp) associated multidrug resistance (MDR) represents a major
failure in cancer treatment. The overexpression of P-gp is responsible for ATP-dependent …

Breast cancer is the most frequent malignancy affecting women, yet current therapeutic
strategies remain ineffective for patients with late‐stage or metastatic disease. Here an …

Background Polyamidoamine (PAMAM) dendrimer applications have extended from tumor
cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant …

In this study, in-silico properties of Gingerol (Gin) and Letrozole (Let), as two potential anti-
cancer drugs, were investigated and some significant ADME drawbacks were predicted …

Transition metal coordination compounds play an important role in the treatment of
neoplastic diseases. However, due to their low selectivity and bioavailability, as well as the …

Breast cancer is the most common malignancy in women. Although personalized or
targeting molecular cancer therapy is more popular up to now, the cytotoxicity chemotherapy …

Biodegradable nanopolymers are believed to offer great potential in cancer therapy. Here,
we report the characterization of a novel, targeted, nanobiopolymeric conjugate based on …

Breast cancer is the most frequently occurring cancer among women throughout the world.
Natural compounds such as curcumin hold promise to treat a variety of cancers including …

Understanding the molecular features responsible for the plasma kinetics of surface-
modified polyamido amine (PAMAM) dendrimers is critical to explore novel biomedical …