Margetuximab conjugated-PEG-PAMAM G4 nano-complex: a smart nano-device for suppression of breast cancer

Y Khakinahad, S Sohrabi, S Razi, A Narmani… - Biomedical Engineering …, 2022 - Springer
Breast cancer due to its high incidence and mortality is the second leading cause of death
among females. On the other hand, nanoparticle-based drug delivery is one of the most …

PE38-based gene therapy of HER2-positive breast cancer stem cells via VHH-redirected polyamidoamine dendrimers

C Moradian, F Rahbarizadeh - Scientific Reports, 2021 - nature.com
Breast cancer stem cells (BCSCs) resist conventional treatments and cause tumor
recurrence. Almost 25% of breast cancers overexpress human epidermal growth factor …

siRNA targeting mcl-1 potentiates the anticancer activity of andrographolide nanosuspensions via apoptosis in breast cancer cells

S Pengnam, P Charoensuksai, B Yingyongnarongkul… - Pharmaceutics, 2022 - mdpi.com
Breast cancer is the second leading cause of cancer-related death in the US. However,
recurrence is frequently found despite adjuvant therapy being available. Combination …

[HTML][HTML] MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer

Q Huang, L Li, L Li, H Chen, Y Dang, J Zhang, N Shao… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and the five-
year survival rate is lower in advanced NSCLC patients. Chemotherapy is a widely used …

Cerulenin suppresses ErbB2-overexpressing breast cancer by targeting ErbB2/PKM2 pathway

S Lv, Y Zhang, J Song, J Chen, B Huang, Y Luo… - Medical Oncology, 2022 - Springer
Cerulenin is a fungal metabolite and a specific inhibitor of fatty acid synthase (FASN), which
has shown a potential anticancer activity. 20–25% of breast cancer patients with ErbB2 …

Selective cytotoxicity of PAMAM G5 core–PAMAM G2. 5 shell tecto-dendrimers on melanoma cells

P Schilrreff, C Mundiña-Weilenmann… - International Journal …, 2012 - Taylor & Francis
Background The controlled introduction of covalent linkages between dendrimer building
blocks leads to polymers of higher architectural order known as tecto-dendrimers. Because …

Recent advances in dendrimer-based nanoplatform for cancer treatment: A review

RS Ambekar, M Choudhary… - European polymer …, 2020 - Elsevier
Out of the total deaths, 70% death occurs in middle and low-income countries due to cancer
and according to world cancer report 2014, total annual economic cost of cancer in 2010 …

The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers

S Wang, Y Li, J Fan, Z Wang, X Zeng, Y Sun, P Song… - Biomaterials, 2014 - Elsevier
Abstract Poly (amidoamine)(PAMAM) dendrimers, are among the most common classes of
dendrimers that are intended for a wide range of biomedical applications and extensively …

Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death

J Liang, X Tian, M Zhou, F Yan, J Fan, Y Qin, B Chen… - Biomaterials, 2024 - Elsevier
Necroptotic immunogenic cell death (ICD) can activate the human immune system to treat
the metastasis and recurrence of triple-negative breast cancer (TNBC). However …

Intratumor performance and therapeutic efficacy of PAMAM dendrimers carried by clustered nanoparticles

HJ Li, J Liu, YL Luo, SB Chen, R Liu, JZ Du… - Nano Letters, 2019 - ACS Publications
In recent years, small nanoparticles (NPs) with a diameter of less than 10 nm have aroused
considerable interest in biomedical applications. However, their intratumor performance, as …