Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and
solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly …

The objective of this study is to make comprehensive cytotoxicity evaluation and in vitro
characterization of Jeffamine-cored polyamidoamine (PAMAM) dendrimers on L929 cell …

PAMAM dendrimers (PAMs) are a group of polymeric macromolecules with distinctive
physicochemical features, which can make them multifunctional theranostic nanoparticles …

Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers
are already successfully used in experimental gene therapies, but despite advantages such …

In part I of this review, the authors showed how poly (amidoamine)(PAMAM)-based
dendrimers can be considered as promising delivering platforms for siRNA therapeutics …

Skin cancer is currently diagnosed as one in every three cancers. Melanoma, the most
aggressive form of skin cancer, is responsible for 79% of skin cancer deaths and the …

PAMAM dendrimers are a novel class of spherical, well-designed branching polymers with
interior cavities and abundant terminal groups on the surface which can form stable …

Multidrug resistance (MDR) is a major obstacle to the chemotherapeutic treatment of breast
cancer. Germacrone, the main component of Rhizoma Curcuma, has been shown to …

Background It is well-established that specific herbal plants contain natural active
ingredients that have demonstrated anti-cancer potential. Therefore, they are considered …

The fourth generation (G4) of poly (amidoamine) dendrimer was PEGylated and then
physically incorporated with carboplatin to develop the new drug delivery carrier. The proton …