Medical therapy for heart failure caused by ischemic heart disease

IY Elgendy, D Mahtta, CJ Pepine - Circulation research, 2019 - Am Heart Assoc
Patients with heart failure (HF) syndromes have been categorized as those with reduced
ejection fraction (EF) or preserved EF (HFpEF), and ischemia plays a key role in both types …

Heart failure with preserved ejection fraction: from mechanisms to therapies

CSP Lam, AA Voors, RA de Boer… - European heart …, 2018 - academic.oup.com
This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …

Heart failure with preserved ejection fraction: new approaches to diagnosis and management

B Upadhya, DW Kitzman - Clinical cardiology, 2020 - Wiley Online Library
The majority of older patients who develop heart failure (HF), particularly older women, have
a preserved left ventricular ejection fraction (HFpEF). Patients with HFpEF have severe …

Heart failure with preserved ejection fraction

JD Gladden, AH Chaanine… - Annual review of …, 2018 - annualreviews.org
Heart failure (HF) is a clinical syndrome of diverse etiologies and can be associated with
preserved, reduced, or mid-range ejection fraction (EF). In the community, heart failure with …

The pathophysiology of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2014 - nature.com
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …

Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction

RJ Mentz, JP Kelly, TG von Lueder, AA Voors… - Journal of the American …, 2014 - jacc.org
Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure
with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction …

Heart failure with preserved ejection fraction: a clinical dilemma

M Komajda, CSP Lam - European heart journal, 2014 - academic.oup.com
Heart failure with preserved ejection fraction (HFpEF) is now recognized as a major and
growing public health problem worldwide. Yet significant uncertainties still surround its …

Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies

K Sharma, DA Kass - Circulation research, 2014 - Am Heart Assoc
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

Developing new treatments for heart failure: focus on the heart

M Gheorghiade, CJ Larson, SJ Shah… - Circulation: Heart …, 2016 - Am Heart Assoc
Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous
advancement in therapy for ambulatory HF with reduced ejection fraction with the use of …

Developing therapies for heart failure with preserved ejection fraction: current state and future directions

J Butler, GC Fonarow, MR Zile, CS Lam, L Roessig… - JACC: Heart Failure, 2014 - jacc.org
The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is
projected to worsen. To date, there are no approved therapies available for reducing …