Effective T cell responses against infections and tumors require a swift and ample
production of cytokines, chemokines, and cytotoxic molecules. The production of these …

T cells are central players of the adaptive immune system by protecting us from recurring
infections and by killing malignant cells. Protective T cell responses rely on the concerted …

Signaling downstream of the T cell receptor (TCR) is directly regulated by the dose and
affinity of peptide antigen. The strength of TCR signaling drives a multitude of T cell functions …

The relationship between the extrinsic environment and the internal transcriptional network
is circular. Naive T cells first engage with antigen‐presenting cells to set transcriptional …

Immunity to intracellular pathogens and cancer relies on the generation of robust CD8+ T
cell effector responses as well as the establishment of immunological memory. During a …

Cytotoxic T-cells are crucial to protect us from intracellular pathogens and malignant cells.
When T-cells become activated, they rapidly secrete cytokines, chemokines and cytotoxic …

The immune system is under strict regulatory control to ensure homeostasis of inflammatory
responses, lying dormant when not needed but quick to act when called upon. Small …

T helper cell subsets orchestrate context-and pathogen-specific responses of the immune
system. They mostly do so by secreting specific cytokines that attract or induce activation …

Th cell lineage determination and functional specialization are tightly linked to the activation
of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These …

Chronic viral infections and cancer often lead to the emergence of dysfunctional or
'exhausted'CD8+ T cells, and the restoration of their functions is currently the focus of …