Superantigens (SAgs) are extremely potent bacterial toxins, which evoke a virulent immune
response, inducing nonspecific T-cell proliferation, rapid cytokine release, and lethal toxic …

Bacterial superantigens have been implicated in the pathogenesis of several human
diseases. Among them, toxic shock syndrome (TSS) is a prototypic acute intoxication caused …

Superantigens trigger an excessive cellular immune response, leading to toxic shock. We
have designed a peptide antagonist that inhibits superantigen-induced expression of human …

Toxic shock syndrome induced by superantigens such as TSST-1 is characterized by the
production of lethal proinflammatory cytokines associated with a T helper 1 (T [sub H] I1) …

Superantigens secreted by Staphylococcus aureus and Streptococcus pyogenes interact
with the T-cell receptor and major histocompatibility class II molecules on antigen-presenting …

Bacterial superantigens trigger an excessive, Th1-cytokine response leading to toxic shock.
We designed a peptide antagonist that inhibits SEB-induced expression of human genes for …

TSST-1 is a Staphylocoaus aureus-derived superantigen which has been implicated in the
pathogenesis of toxic shock syndrome. In mice, superantigen-induced prolifetation is …

Staphylococcus aureus and group A Streptococcus pyogenes (GAS) express superantigen
(SAg) exotoxin proteins capable of inducing lethal shock. To induce toxicity, SAgs must bind …

Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to
activate large numbers of T cells simultaneously. SAgs activate T cells by direct binding and …

Toxic shock syndrome (TSS) is caused by staphylococcal and streptococcal superantigens
(SAgs) that provoke a swift hyperinflammatory response typified by a cytokine storm. The …