[HTML][HTML] Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia
MJ Simon, T Logan, SL DeVos, G Di Paolo - Trends in Cell Biology, 2023 - cell.com
Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
[HTML][HTML] The lysosomal function of progranulin, a guardian against neurodegeneration
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …
implicated in a multitude of processes ranging from regulation of inflammation to wound …
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes
Y Tanaka, G Suzuki, T Matsuwaki… - Human molecular …, 2017 - academic.oup.com
Progranulin (PGRN) haploinsufficiency resulting from loss-of-function mutations in the
PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 …
PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 …
Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN …
Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
X Zhou, L Sun, F Bastos de Oliveira, X Qi… - Journal of Cell …, 2015 - rupress.org
Mutations in the progranulin (PGRN) gene have been linked to two distinct
neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal …
neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal …
[HTML][HTML] Progranulin as a therapeutic target in neurodegenerative diseases
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
[HTML][HTML] Progranulin deficiency leads to reduced glucocerebrosidase activity
Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-
dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar …
dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar …
[PDF][PDF] Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava… - Cell, 2021 - cell.com
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin
(PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn …
(PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn …
[HTML][HTML] Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene
causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a …
causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a …