Introduction By improving our understanding of the neurobiological mechanisms underlying
addiction, neuroimaging research is helping to identify new targets for personalized …

Identifying addicts with higher risk of relapse would provide the opportunity to implement
individualized interventions and increase cessation success rates. Unfortunately, the ability …

Introduction Research on cigarette smokers suggests cognitive and behavioral impairments.
However, much remains unclear how the functional neurobiology of smokers is influenced …

Background Inherited differences in the rate of metabolism of nicotine, the addictive
chemical in tobacco, affect smoking behavior and quitting success. The nicotine metabolite …

Neurobiological models of addiction attribute vulnerability to compulsive drug use to
dysregulated activity within the neural networks that underlie reward and executive …

For the past 30 years, research examining predictors of successful smoking cessation
treatment response has focused primarily on clinical variables, such as levels of tobacco …

Tobacco smoking is one of the leading causes of preventable death and disease worldwide.
Most smokers want to quit, but relapse rates are high. To improve current smoking cessation …

To date, fractionation of the nicotine addiction phenotype has been limited to that based
primarily on characteristics of cigarette use, although it is widely appreciated that a variety of …

Cigarette smoking is a significant public health concern, often resulting in nicotine
dependence, a chronic-relapsing psychiatric diagnosis that is responsible for up to 10% of …

Introduction: The reasons that some smokers find it harder to quit than others are unclear.
Understanding how individual differences predict smoking cessation outcomes may allow …