[HTML][HTML] The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent
S Skopelja-Gardner, J An, J Tai, L Tanaka, X Sun… - Scientific reports, 2020 - nature.com
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light
(UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease …
(UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease …
Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells
Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in
systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are …
systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are …
Ultraviolet B irradiation causes stimulator of interferon genes–dependent production of protective type I interferon in mouse skin by recruited inflammatory monocytes
C Sontheimer, D Liggitt, KB Elkon - Arthritis & Rheumatology, 2017 - Wiley Online Library
Objective Photosensitivity is common in patients with systemic lupus erythematosus,
although the mechanisms linking ultraviolet (UV) light to flares are not well understood. We …
although the mechanisms linking ultraviolet (UV) light to flares are not well understood. We …
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa
Objective Skin inflammation and photosensitivity are common in patients with cutaneous
lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known …
lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known …
Ultraviolet light protection by a sunscreen prevents interferon‐driven skin inflammation in cutaneous lupus erythematosus
S Zahn, M Graef, N Patsinakidis… - Experimental …, 2014 - Wiley Online Library
Irradiation with ultraviolet (UV) light is an important exacerbating factor in cutaneous lupus
erythematosus (CLE) and induces various effects in the skin of patients with the disease …
erythematosus (CLE) and induces various effects in the skin of patients with the disease …
Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients
E Reefman, H Kuiper, PC Limburg… - Annals of the …, 2008 - ard.bmj.com
Objective: To investigate the involvement of type I interferons and endothelial cell adhesion
molecules in the development of ultraviolet B (UVB)-induced systemic lupus erythaematosus …
molecules in the development of ultraviolet B (UVB)-induced systemic lupus erythaematosus …
[HTML][HTML] Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus
A Kuhn, K Fehsel, P Lehmann, J Krutmann… - Journal of Investigative …, 1998 - Elsevier
Photosensitivity is a main criterion for the diagnosis of systemic lupus erythematosus (LE),
and ultraviolet (UV) irradiation plays a key role in the pathogenesis of cutaneous LE …
and ultraviolet (UV) irradiation plays a key role in the pathogenesis of cutaneous LE …
The influence of interferon on healthy and diseased skin
GA Hile, JE Gudjonsson, JM Kahlenberg - Cytokine, 2020 - Elsevier
Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect
against viral and bacterial infection. In addition, mounting evidence suggests IFNs …
against viral and bacterial infection. In addition, mounting evidence suggests IFNs …
[HTML][HTML] Human and murine evidence for mechanisms driving autoimmune photosensitivity
SJ Wolf, SN Estadt, JE Gudjonsson… - Frontiers in …, 2018 - frontiersin.org
Ultraviolet (UV) light is an important environmental trigger for systemic lupus erythematosus
(SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known …
(SLE) patients, yet the mechanisms by which UV light impacts disease are not fully known …
[HTML][HTML] Lupus skin is primed for IL-6 inflammatory responses through a keratinocyte-mediated autocrine type I interferon loop
JN Stannard, TJ Reed, E Myers, L Lowe… - Journal of Investigative …, 2017 - Elsevier
Cutaneous lupus erythematosus is a disfiguring and common manifestation in systemic
lupus erythematosus, and the etiology of this predisposition for cutaneous inflammation is …
lupus erythematosus, and the etiology of this predisposition for cutaneous inflammation is …