Results from short-term tests for carcinogens and our advanced knowledge on cellular and
molecular mechanisms of carcinogenesis strongly suggest that carcinogens do not induce …

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor
genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap …

Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …

Gap junctional intercellular communication mediates the transfer of small molecules from the
cytoplasm of one cell to that of neighbouring cells. Connexins are the proteins that form the …

Gap junctional intercellular communication plays a key role in the maintenance of
homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells …

Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …

During multistage carcinogenesis, the functions of several key genes involved in cell growth
control must be damaged. Such genes include not only those involved in cell cycle control of …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

It is widely accepted that a series of genetic changes accumulate during carcinogenesis. In
addition, it is likely that various non-genotoxic mechanisms also operate at different stages …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …