Organic transistors incorporating lipid monolayers for drug interaction studies

P Cavassin, AM Pappa, C Pitsalidis… - Advanced Materials …, 2020 - Wiley Online Library
Cell membranes are fundamental for cellular function as they protect the cell and control
passage in and out of the cell. Despite their clear significance, cell membranes are often …

Understanding electrochemical properties of supported lipid bilayers interfaced with organic electronic devices

Z Lu, D van Niekerk, A Savva, K Kallitsis… - Journal of Materials …, 2022 - pubs.rsc.org
Supported lipid bilayers (SLBs) are cell–membrane-mimicking platforms of varying
biological complexity, that can be formed on solid surfaces and used to characterise the …

Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors

MD Angione, S Cotrone, M Magliulo… - Proceedings of the …, 2012 - National Acad Sciences
Biosystems integration into an organic field-effect transistor (OFET) structure is achieved by
spin coating phospholipid or protein layers between the gate dielectric and the organic …

Volatile general anesthetic sensing with organic field-effect transistors integrating phospholipid membranes

MD Angione, M Magliulo, S Cotrone, A Mallardi… - Biosensors and …, 2013 - Elsevier
The detailed action mechanism of volatile general anesthetics is still unknown despite their
effect has been clinically exploited for more than a century. Long ago it was also assessed …

Biophysical interactions with model lipid membranes: applications in drug discovery and drug delivery

C Peetla, A Stine, V Labhasetwar - Molecular pharmaceutics, 2009 - ACS Publications
The transport of drugs or drug delivery systems across the cell membrane is a complex
biological process, often difficult to understand because of its dynamic nature. In this regard …

Electrochemical properties of phospholipid monolayers at liquid–liquid interfaces

HA Santos, V García‐Morales, CM Pereira - ChemPhysChem, 2010 - Wiley Online Library
Biomembrane models built at the interface between two immiscible electrolytes (ITIES) are
useful systems to study phenomena of biological relevance by means of their …

Analytical techniques and methods for study of drug-lipid membrane interactions

H Li, T Zhao, Z Sun - Reviews in Analytical Chemistry, 2018 - degruyter.com
A better elucidation of molecular mechanisms underlying drug-membrane interaction is of
great importance for drug research and development. To date, different biochemical and …

Lipid bilayer formation on organic electronic materials

Y Zhang, S Wustoni, A Savva, A Giovannitti… - Journal of Materials …, 2018 - pubs.rsc.org
The lipid bilayer is the elemental structure of a cell membrane, forming a stable barrier
between the interior and exterior of the cell while hosting membrane proteins that enable …

Electrochemistry at Lipid Monolayer-Modified Liquid− Liquid Interfaces as an Improvement to Drug Partitioning Studies

A Mälkiä, P Liljeroth, AK Kontturi… - The Journal of Physical …, 2001 - ACS Publications
The drug partitioning between membrane and solution has traditionally been approached
with bulk thermodynamic models, such as the octanol− water partitioning system. This …

Lipid Microfluidic Biomimetic Models for Drug Screening: A Comprehensive Review

E Fernandes, VF Cardoso… - Advanced Functional …, 2024 - Wiley Online Library
Developing new drugs is a complex, time‐consuming, and expensive process, essential to
identify potential pharmacokinetic issues in the early stages to avoid investment in …