Design and synthesis of new anticancer pyrimidines with multiple-kinase inhibitory effect
IM El-Deeb, SH Lee - Bioorganic & medicinal chemistry, 2010 - Elsevier
A new series of N-substituted-2-aminopyrimidines based on the '4-(pyridin-3-yl) pyrimidin-2-
amine'scaffold of Imatinib has been designed and synthesized. A selected group from the …
amine'scaffold of Imatinib has been designed and synthesized. A selected group from the …
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2, 6, 9-Trisubstituted Purine Derivatives as Potential Agents for …
J Bertrand, H Dostálová, V Kryštof, R Jorda, T Delgado… - Pharmaceutics, 2022 - mdpi.com
We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and
FLT3-ITD as part of our program to develop 2, 6, 9-trisubstituted purine derivatives as …
FLT3-ITD as part of our program to develop 2, 6, 9-trisubstituted purine derivatives as …
Exploration of N-(2-aminoethyl) piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor
VEGFR, ERK and Abl had been respectively identified as good drug targets, and their
crosstalk also had been well elaborated. Multitarget drugs were more advantageous for …
crosstalk also had been well elaborated. Multitarget drugs were more advantageous for …
2, 4-Diaryl-pyrimido [1, 2-a] benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and …
MA Shaldam, D Hendrychová, R El-Haggar… - European Journal of …, 2023 - Elsevier
Acute myeloid leukemia (AML) stands as one of the most aggressive type of human cancer
that can develop rapidly and thus requires immediate management. In the current study, the …
that can develop rapidly and thus requires immediate management. In the current study, the …
A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity
Herein, we report the synthesis and cytotoxic effects of novel chlorinated plastoquinone
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …
Synthesis, docking and cytotoxicity evaluation of N-(5-(benzyl-thio)-1, 3, 4-thiadiazol-2-yl)-2-(3-methoxyphenyl) acetamide derivatives as tyrosine kinase inhibitors with …
A Mohammadi-Farani, T Bahrami… - Journal of Reports in …, 2014 - journals.lww.com
In the recent years, targeted therapy of the neoplastic diseases is a current strategy used by
oncologists. Hence, design and discovery of novel targeted anticancer therapeutics is an …
oncologists. Hence, design and discovery of novel targeted anticancer therapeutics is an …
Design, synthesis, antitumor activity and molecular docking study of novel 5-deazaalloxazine analogs
S Mahmoud, D Samaha, MS Mohamed… - Molecules, 2020 - mdpi.com
Protein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein,
we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted …
we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted …
Synthesis and biological evaluation of novel aromatic amide derivatives as potential BCR-ABL inhibitors
X Wang, Z Xu, J Feng, G Pan, X He, M Lv… - Bioorganic & Medicinal …, 2023 - Elsevier
BCR-ABL1 kinase is a key driver of the pathophysiology of chronic myeloid leukemia (CML).
Current treatments need to broaden the chemical diversity of BCR-ABL1 kinase inhibitors to …
Current treatments need to broaden the chemical diversity of BCR-ABL1 kinase inhibitors to …
Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors
C Zhang, C Tan, X Zu, X Zhai, F Liu, B Chu… - European journal of …, 2011 - Elsevier
Based on the literature-reported compensatory effect of PI3K on Abl inhibition and the
improved preclinical effect of drug combination of Abl and PI3K inhibitors, a series of …
improved preclinical effect of drug combination of Abl and PI3K inhibitors, a series of …
Benzimidazole‐based protein kinase inhibitors: Current perspectives in targeted cancer therapy
Targeted therapy has emerged to be the cornerstone of advanced cancer treatment,
allowing for more selectivity and avoiding the common drug toxicity and resistance …
allowing for more selectivity and avoiding the common drug toxicity and resistance …