Modification, Biological Evaluation and 3D QSAR Studies of Novel 2-(1,3-Diaryl- 4,5-Dihydro-1H-Pyrazol-5-yl)Phenol Derivatives as Inhibitors of B-Raf Kinase
YS Yang, F Zhang, DJ Tang, YH Yang, HL Zhu - PloS one, 2014 - journals.plos.org
A series of novel 2-(1, 3-diaryl-4, 5-dihydro-1 H-pyrazol-5-yl) phenol derivatives (C1–C24)
have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these …
have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these …
Novel 7-chloro-4-aminoquinoline-benzimidazole hybrids as inhibitors of cancer cells growth: synthesis, antiproliferative activity, in silico ADME predictions, and …
In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …
Identification of novel inhibitors of BCR-ABL tyrosine kinase via virtual screening
Inhibition of BCR-ABL tyrosine kinase activity has shown to be essential for the treatment of
chronic myelogenous leukemia (CML). However, drug resistance has quickly arisen in …
chronic myelogenous leukemia (CML). However, drug resistance has quickly arisen in …
Design, synthesis, and biological activity of 4-(imidazo [1, 2-b] pyridazin-3-yl)-1H-pyrazol-1-yl-phenylbenzamide derivatives as BCR–ABL kinase inhibitors
L Hu, T Cao, Y Lv, Y Ding, L Yang, Q Zhang… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract A series of 4-((pyrazolo [1, 5-a] pyrimidin-6-yl)-1H-pyrazol-1-yl) phenyl-3-
benzamide derivatives and 4-((imidazo [1, 2-b] pyridazin-3-yl)-1H-pyrazol-1-yl-) phenyl-3 …
benzamide derivatives and 4-((imidazo [1, 2-b] pyridazin-3-yl)-1H-pyrazol-1-yl-) phenyl-3 …
New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
HM Al-Tuwaijri, ES Al-Abdullah, AA El-Rashedy… - Molecules, 2023 - mdpi.com
In this research study, the authors successfully synthesized potent new anticancer agents
derived from indazol-pyrimidine. All the prepared compounds were tested for in vitro cell line …
derived from indazol-pyrimidine. All the prepared compounds were tested for in vitro cell line …
Discovery of New Quinoline-Based Diarylamides as Potent B-RAFV600E/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity
The emergence of cancer resistance to targeted therapy represents a significant challenge
in cancer treatment. Therefore, identifying new anticancer candidates, particularly those …
in cancer treatment. Therefore, identifying new anticancer candidates, particularly those …
Novel butein derivatives repress DDX3 expression by inhibiting PI3K/AKT signaling pathway in MCF-7 and MDA-MB-231 cell lines
S Rampogu, SM Kim, B Shaik, G Lee, JH Kim… - Frontiers in …, 2021 - frontiersin.org
Background Breast cancer is one of the major causes of mortalities noticed in women
globally. DDX3 has emerged as a potent target for several cancers, including breast cancer …
globally. DDX3 has emerged as a potent target for several cancers, including breast cancer …
Design and synthesis of benzofuro [3, 2-b] pyridin-2 (1H)-one derivatives as anti-leukemia agents by inhibiting Btk and PI3Kδ
L Liu, B Shi, X Li, X Wang, X Lu, X Cai, A Huang… - Bioorganic & Medicinal …, 2018 - Elsevier
Btk inhibitors and PI3Kδ inhibitors play crucial roles in the treatment of leukemia, and studies
confirmed that the synergetic inhibition against Btk and PI3Kδ could gain an optimal …
confirmed that the synergetic inhibition against Btk and PI3Kδ could gain an optimal …
Rationale Design, Synthesis And In Vitro Anticancer Activity of New 2,5‐Disubstituted‐1,3,4‐Oxadiazole Analogues
MJ Ahsan - ChemistrySelect, 2016 - Wiley Online Library
Two new series of oxadiazole analogues (4a–e and 4f–j) were designed based on
heterocyclic (1, 3, 4‐oxadiazole) linked aryl core of IMC‐038525 (tubulin polymerization …
heterocyclic (1, 3, 4‐oxadiazole) linked aryl core of IMC‐038525 (tubulin polymerization …
Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E
Thiourea derivatives of uracil were efficiently synthesized via the reaction of 5-aminouracil
with isothiocyanates. Then, we prepared uracil-containing thiazoles via condensation of …
with isothiocyanates. Then, we prepared uracil-containing thiazoles via condensation of …