Synthesis, in vitro antiproliferative activity, and kinase inhibitory effects of pyrazole-containing diarylureas and diarylamides
MI El-Gamal, BJ Park, CH Oh - European Journal of Medicinal Chemistry, 2018 - Elsevier
Twenty pyrazole-containing diarylureas and diarylamides were designed and synthesized.
They were tested for in vitro antiproliferative activity over a 58-cancer cell line panel at the …
They were tested for in vitro antiproliferative activity over a 58-cancer cell line panel at the …
Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives
C Wang, M Zhu, X Long, Q Wang, Z Wang… - International Journal of …, 2023 - mdpi.com
A series of indazole derivatives were designed and synthesized by molecular hybridization
strategy, and these compounds were evaluated the inhibitory activities against human …
strategy, and these compounds were evaluated the inhibitory activities against human …
[PDF][PDF] Exploration of anticancer potential of novel pyrrolo [2, 3-b] pyridine derivatives targeting V600E-BRAF kinase: molecular docking, pharmacokinetic and DFT …
Cancer is a type of disease that causes a threat to human health and human1life [1, 2]. In
recent years, the morbidity rate of cancer has increased [3, 4]. Cell proliferation is triggered …
recent years, the morbidity rate of cancer has increased [3, 4]. Cell proliferation is triggered …
Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
Anti cancer, molecular docking and structure activity relationship studies of some novel synthetic spiroindolo [3, 2-b] carbazoles as predicted HER2 and BrK kinase …
MT El Sayed, A Voronkov, IV Ogungbe… - Current Bioactive …, 2018 - ingentaconnect.com
Background: Spirocyclic compounds are important because of their unique structure and
diverse biological activities. The indolo-spirocyclic scaffold is regularly found as a core …
diverse biological activities. The indolo-spirocyclic scaffold is regularly found as a core …
Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment
Cancer is a challenging and second most deadly disease. The epidermal growth factor
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
[PDF][PDF] Synthesis, molecular modeling studies and biological evaluation of novel pyrazole derivatives as antitumor and EGFR inhibitors
S Walaa, NA Mohamed, S Weam, ES Nossier… - Int. J. Pharm …, 2016 - researchgate.net
In this study, a new series of 4-(5-methylisoxazol-3-ylamino) thiazole derivatives
incorporated with different heterocyclic moieties was synthesized and screened for their in …
incorporated with different heterocyclic moieties was synthesized and screened for their in …
Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity
AK El-Damasy, H Jin, JW Park, HJ Kim… - Journal of Enzyme …, 2023 - Taylor & Francis
The design of kinase inhibitors targeting the oncogenic kinase BCR-ABL constitutes a
promising paradigm for treating chronic myeloid leukaemia (CML). Nevertheless, the …
promising paradigm for treating chronic myeloid leukaemia (CML). Nevertheless, the …
Design, synthesis, anticancer evaluation, and molecular docking studies of thiazole–pyrimidine linked amide derivatives
A library of new amide-based thiazole–pyrimidines (13a–j) was designed by considering
vital pharmacophoric features of the potential multi-acting anticancer agents. The analogs …
vital pharmacophoric features of the potential multi-acting anticancer agents. The analogs …
Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents
In an attempt to find potential anticancer agents, a series of novel ethyl 4-(3-(aryl)-1-phenyl-
1H-pyrazol-4-yl)-2-oxo-6-(pyridin-3-yl) cyclohex-3-enecarboxylates 5a-i and 5-(3-(4 …
1H-pyrazol-4-yl)-2-oxo-6-(pyridin-3-yl) cyclohex-3-enecarboxylates 5a-i and 5-(3-(4 …