Abnormal signalling from the Protein tyrosine kinases (PTKs) like receptor tyrosine kinases
and intracellular tyrosine kinases can lead to diseases such as cancer especially non-small …

Novel derivatives of 2-amino benzothiazoles 4 (a–j) have been synthesized and tested for
their antitumor activity using National Cancer Institute (NCI) disease oriented antitumor …

Pyrazolo [4, 3-e] tetrazolo [1, 5-b][1, 2, 4] triazine sulfonamides constitute a novel class of
heterocyclic compounds with broad biological activity, including anticancer properties …

Protein kinases are promising therapeutic targets for cancer therapy. Here, we applied
multiple approaches to optimize the potency and selectivity of our reported alloxazine …

Abstract A series of quinazolin-4 (3 H)-one derivatives were synthesised and evaluated for
their cytotoxicity against human Caucasian breast adenocarcinoma (MCF-7) and human …

A novel series of bis (1, 3, 4-thiadiazole) derivatives were synthesized in one step
methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 …

A series of 2-(1 H-indol-3-yl)-5-substituted-1, 3, 4-oxadiazoles, 4a–m, were designed,
synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents …

Abstract A series of 1-(4-chlorobenzhydryl) piperazine derivatives 3–10 were synthesized
and characterized both spectroscopically and structurally to investigate their antiproliferative …

Herein, we designed and synthesized 1, 5-benzodiazepines as a lead molecule for
anticancer activity and as potent synergistic activity with drug Methotrexate. Working under …

Oncology research progresses, yet cancer remains the largest medical need. The use of a
medication with an accessible lead molecule shows great potential for long-term cancer …