Evolutionary trade-offs occur when selection on one trait has detrimental effects on other
traits. In pathogenic microbes, it has been hypothesized that antibiotic resistance trades off …

Bacteria are single-celled organisms, but the survival of microbial communities relies on
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …

Antibiotic treatments increasingly fail due to rapid dissemination of drug resistance.
Comparative genomics of clinical isolates highlights the role of de novo adaptive mutations …

Understanding epistasis is central to biology. For instance, epistatic interactions determine
the topography of the fitness landscape and affect the dynamics and determinism of …

Tackling antibiotic resistance necessitates deep understanding of how resource competition
within and between species modulates the fitness of resistant microbes. Recent advances in …

Understanding the evolution of microorganisms under antibiotic treatments is a burning
issue. Typically, several resistance mutations can accumulate under antibiotic treatment …

Genetic constraints can block many mutational pathways to optimal genotypes in real fitness
landscapes, yet the extent to which this can limit evolution remains to be determined …

Recent research has demonstrated that selection for antibiotic resistance occurs at very low
antibiotic concentrations in single-species experiments, but the relevance of these findings …

In the struggle with antibiotic resistance, we are losing. There is now a serious threat of
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …

Antibiotic resistance represents a growing health crisis that necessitates the immediate
discovery of novel treatment strategies. One such strategy is the identification of collateral …