Most studies on the evolution of antibiotic resistance are focused on selection for resistance
at lethal antibiotic concentrations, which has allowed the detection of mutant strains that …

Because adaptation depends upon the fixation of novel beneficial mutations, the fitness
effects of beneficial mutations that are substituted by selection are key to our understanding …

Understanding the constraints that shape the evolution of antibiotic resistance is critical for
predicting and controlling drug resistance. Despite its importance, however, a systematic …

Revealing the genetic changes responsible for antibiotic resistance can be critical for
developing novel antibiotic therapies. However, systematic studies correlating genotype to …

Multidrug combinations are increasingly important in combating the spread of antibiotic-
resistance in bacterial pathogens,,. On a broader scale, such combinations are also …

Antibiotic resistance is increasing in pathogenic microbial populations and is thus a major
threat to public health. The fate of a resistance mutation in pathogen populations is …

The spread of bacterial antibiotic resistance mutations is thought to be constrained by their
pleiotropic fitness costs. Here we investigate the fitness costs of resistance in the context of …

Populations often encounter changed environments that remove selection for the
maintenance of particular phenotypic traits. The resulting genetic decay of those traits under …

The evolution of bacterial pathogens towards antibiotic resistance is not just a relevant
problem for human health, but a fascinating example of evolution that can be studied in real …

Highlights•The evolution and diversity of metabolic strategies is poorly understood.•Systems
Biology models can predict metabolic strategies from genomic data.•Metabolic strategies …