DNA modifications are used to regulate gene expression and defend against invading
genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine …

Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of
active genes, and the extent of methylation biology conservation is unclear. We quantified …

Chemical modification of nucleotide bases in DNA provides one mechanism for conveying
information in addition to the genetic code. 5-methylcytosine (5mC) represents the most …

Cytosine methylation of DNA is a widespread modification of DNA that plays numerous
critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon …

Summary DNA N 6-methyladenine (6mA) modification is commonly found in microbial
genomes and plays important functions in regulating numerous biological processes in …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …

Transposable elements are in a constant arms race with the silencing mechanisms of their
host genomes. One silencing mechanism commonly used by many eukaryotes is dependent …

The amount of bacterial and archaeal genome sequence and methylome data has greatly
increased over the last decade, enabling new insights into the functional roles of DNA …

In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …