Little is known about how cells regulate and integrate distinct biosynthetic pathways
governing differentiation and cell division. For B lineage cells it is widely accepted that …

B cell–specific gene ablation of Notch2 results in the loss of the marginal zone (MZ) B-cell
lineage. To analyze the effects of constitutive Notch2 signaling in B cells, we have generated …

How activated B cells build biosynthetic pathways and organelle structures necessary for
subsequent robust antibody secretion is still unclear. The dominant model holds that …

B lymphocytes migrate among varied microenvironmental niches during diversification,
selection, and conversion to memory or Ab-secreting plasma cells. Aspects of the nutrient …

Cell division is an essential component of B cell differentiation to Ab-secreting plasma cells,
with critical reprogramming occurring during the initial stages of B cell activation. However, a …

To reconcile conflicting reports on the role of CD40 signaling in germinal center (GC)
formation, we examined the earliest stages of murine GC B cell differentiation. Peri-follicular …

Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal
Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still …

Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells
become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown …

Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct
mature B cell populations in the spleen, originating from a Notch2-dependent fate decision …

Human antibody-secreting cells (ASC) in peripheral blood are found after vaccination or
infection but rapidly apoptose unless they migrate to the bone marrow (BM). Yet, elements of …