A mechanistic account of serotonin's impact on mood
Selective serotonin reuptake inhibitors (SSRIs) constitute a first-line antidepressant
intervention, though the precise cognitive and computational mechanisms that explain …
intervention, though the precise cognitive and computational mechanisms that explain …
Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals
To make good decisions, humans need to learn about and integrate different sources of
appetitive and aversive information. While serotonin has been linked to value-based …
appetitive and aversive information. While serotonin has been linked to value-based …
Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers
Instrumental learning is driven by a history of outcome success and failure. Here, we
examined the impact of serotonin on learning from positive and negative outcomes. Healthy …
examined the impact of serotonin on learning from positive and negative outcomes. Healthy …
The involvement of serotonin in major depression: nescience in disguise?
Moncrieff and colleaguesL umbrella review [1] offers an opportunity to reflect on the
'Serotonin hypothesisL of depression serendipitously developed 50 years ago. The notion …
'Serotonin hypothesisL of depression serendipitously developed 50 years ago. The notion …
Psychological mechanisms and functions of 5-HT and SSRIs in potential therapeutic change: Lessons from the serotonergic modulation of action selection, learning …
Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …
Antidepressant treatment and emotional processing: can we dissociate the roles of serotonin and noradrenaline?
The ability to match individual patients to tailored treatments has the potential to greatly
improve outcomes for individuals suffering from major depression. In particular, while the …
improve outcomes for individuals suffering from major depression. In particular, while the …
'It's the way that you look at it'—a cognitive neuropsychological account of SSRI action in depression
The fact that selective serotonin reuptake inhibitors (SSRIs) have antidepressant effects in
some patients supports the notion that serotonin plays a role in the mode of action of …
some patients supports the notion that serotonin plays a role in the mode of action of …
Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …
despite decades of research. In this paper, we make three major claims. First, serotonin …
Delayed antidepressant efficacy and the desensitization hypothesis
KG Commons, SE Linnros - ACS chemical neuroscience, 2019 - ACS Publications
Many conventional antidepressants can quickly raise the levels of extracellular serotonin,
yet their positive effects on mood ensues only weeks later. This delay in efficacy is a clinical …
yet their positive effects on mood ensues only weeks later. This delay in efficacy is a clinical …
The complex clinical response to selective serotonin reuptake inhibitors in depression: a network perspective
L Boschloo, F Hieronymus, A Lisinski… - Translational …, 2023 - nature.com
The clinical response to selective serotonin reuptake inhibitors (SSRIs) in depression takes
weeks to be fully developed and is still not entirely understood. This study aimed to …
weeks to be fully developed and is still not entirely understood. This study aimed to …