Best Practice Advice 1 A diagnosis of functional heartburn should be considered when
retrosternal burning pain or discomfort persists despite maximal (double-dose) proton pump …

Heartburn is a symptom synonymous with gastroesophageal reflux disease (GERD), but as
our knowledge advances, we find that GERD is a more complex disorder than was originally …

Background When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies
functional esophageal disorders into functional heartburn (FH, with negative reflux‐symptom …

Heartburn is among the most common gastrointestinal symptoms presenting to both
generalist physicians and gastroenterologists. Heartburn that does not respond to traditional …

Background Heartburn that persists despite proton-pump inhibitor (PPI) treatment is a
frequent clinical problem with multiple potential causes. Treatments for PPI-refractory …

There is no clear consensus regarding the precise definition of the term refractory GERD.
GERD can be complicated by reflux esophagitis and peptic esophageal strictures, which …

Functional heartburn (FH) is defined as a functional esophageal disorder characterized by
symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In …

Introduction Heartburn is a frequent symptom occurring in daily clinical practice and is
mainly associated with gastroesophageal reflux disease (GERD). However, it can be …

BACKGROUND Functional heartburn (FH) patients have a profound impact on the response
to anti-reflux therapy of the nonerosive reflux disease (NERD) group as compared to the …

OBJECTIVE: Little is known about esophageal nociceptive thresholds in chronic heartburn
sufferers with normal clinical findings. The aim of this study was to evaluate and to …