The value of bioactive adrenomedullin and dipeptidyl peptidase 3 to predict short-term unfavourable outcomes after cardiac surgery: a prospective cohort study

D van Lier, R Beunders, M Kox… - European Journal of …, 2022 - journals.lww.com
BACKGROUND Adrenomedullin (ADM) is a key regulator of endothelial barrier function and
vascular tone. Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of …

The course of adrenomedullin and endothelin levels in patients with vasodilatory shock after cardiac surgery compared to patients after uncomplicated elective cardiac …

P Hillinger, VD Mayr, M Luger, H Tauber, G Luckner… - Journal of Critical …, 2022 - Elsevier
Purpose The aim of this study was to analyse the course of adrenomedullin (ADM) and
endothelin-1 (ET-1) levels in patients with vasodilatory shock after cardiac surgery and to …

Proenkephalin A and bioactive adrenomedullin are useful for risk prognostication in cardiac surgery

A Hill, D Bergmann, J Schulte, R Zayat… - Frontiers in …, 2023 - frontiersin.org
Introduction Various clinical scores have been developed to predict organ dysfunction and
mortality in patients undergoing cardiac surgery, but outcome prediction may be inaccurate …

Postoperatively increased bioactive adrenomedullin is related to adverse outcome after complex aortic surgery

A Gombert, P Doukas, G Marx, O Hartmann… - Vasa, 2020 - econtent.hogrefe.com
Background: Open and endovascular thoracoabdominal aortic aneurysm repair is related to
major complications and increased mortality rates. Up to now, specific biomarkers for …

Bioactive adrenomedullin (bio-ADM) is associated with endothelial dysfunction in infants and children with complex congenital heart disease undergoing open-heart …

M Schaefer, A Stein, B Ruf, G Balling… - Clinical Chemistry and …, 2024 - degruyter.com
Objectives Children with congenital heart disease (CHD) undergoing cardiac surgery on
cardiopulmonary bypass (CPB) are at risk for systemic inflammation leading to endothelial …

Elevated plasma bioactive adrenomedullin and mortality in cardiogenic shock: results from the OptimaCC trial

K Takagi, B Levy, A Kimmoun, Ò Miró, K Duarte… - Journal of Clinical …, 2021 - mdpi.com
Aims: Bioactive adrenomedullin (bio-ADM) was recently shown to be a prognostic marker in
patients with acute circulatory failure. We investigate the association of bio-ADM with organ …

Adrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock

H Tolppanen, M Rivas-Lasarte, J Lassus… - Annals of intensive …, 2017 - Springer
Abstract Background The clinical CardShock risk score, including baseline lactate levels,
was recently shown to facilitate risk stratification in patients with cardiogenic shock (CS). As …

Plasma adrenomedullin in critically ill patients with sepsis after major surgery: a pilot study

TP Simon, L Martin, S Doemming, A Humbs… - Journal of critical …, 2017 - Elsevier
Purpose Adrenomedullin is released by different tissues in hypoxia, oxidative stress, and
inflammation and is found in general and medical patients and, recently, in sepsis patients in …

Adrenomedullin is associated with surgical trauma and impaired renal function in vascular surgery patients

HJ Gillmann, A Meinders, J Larmann… - Journal of intensive …, 2019 - journals.sagepub.com
Background: Patients undergoing vascular surgery are prone to perioperative organ injury
because of both higher prevalence of cardiovascular risk factors and the extent of surgery …

Postoperative bioactive adrenomedullin is associated with the onset of ARDS and adverse outcomes in patients undergoing open thoracoabdominal aortic surgery

P Doukas, O Hartmann, J Frankort, B Arlt, H Krabbe… - Scientific Reports, 2024 - nature.com
Cytokine-mediated systemic inflammation after open thoracoabdominal aortic aneurysm
(TAAA) repairs plays a pivotal role in disrupting circulatory homeostasis, potentially leading …