In silico drug discovery of melatonin receptor ligands with therapeutic potential
Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …
[PDF][PDF] MT2 Selective melatonin receptor antagonists: design and structure-activity relationships
The neurohormone melatonin is involved in the regulation of many physiological functions,
in particular those related to circadian and seasonal rhythms. In mammals, melatonin …
in particular those related to circadian and seasonal rhythms. In mammals, melatonin …
Recent advances in the development of melatonin MT1 and MT2 receptor agonists
Importance of the field: Increasing clinical evidences suggest that melatonin receptor
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …
Structure-Based Virtual Screening of MT2 Melatonin Receptor: Influence of Template Choice and Structural Refinement
Developing GPCR homology models for structure-based virtual screening requires the
choice of a suitable template and refinement of binding site residues. We explored this …
choice of a suitable template and refinement of binding site residues. We explored this …
Structure-based discovery of potent and selective melatonin receptor agonists
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are
important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here …
important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here …
Docking studies for melatonin receptors
HA Alkozi, JM Sanchez Montero… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Melatonin is a neurohormone that controls many relevant physiological
processes beyond the control of circadian rhythms. Melatonin's actions are carried out by …
processes beyond the control of circadian rhythms. Melatonin's actions are carried out by …
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines
Molecular superposition models guided the design of novel melatonin receptor ligands
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …
Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models
Three-dimensional homology models of human MT1 and MT2 melatonin receptors were
built with the aim to investigate the structure− activity relationships (SARs) of MT2 selective …
built with the aim to investigate the structure− activity relationships (SARs) of MT2 selective …
A molecular and chemical perspective in defining melatonin receptor subtype selectivity
KH Chan, YH Wong - International Journal of Molecular Sciences, 2013 - mdpi.com
Melatonin is primarily synthesized and secreted by the pineal gland during darkness in a
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …
Molecular basis of ligand selectivity for melatonin receptors
Sleep disorders in adults are related to adverse health effects such as reduced quality of life
and increased mortality. About 30–40% of adults are suffering from different sleep disorders …
and increased mortality. About 30–40% of adults are suffering from different sleep disorders …