Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

Numerous diseases have been linked to the malfunction of G-protein coupled receptors (GP-
CRs). Their adequate treatment requires rational design of new high-affinity and high …

Melatonin is a neurohormone that translates the circadian rhythm to the peripheral organs
through a series of binding sites identified as G protein‐coupled receptors MT1 and MT2 …

The hormone melatonin is released following a circardian rhythm with highest levels during
the subjective night. It regulates a variety of physiological and neuroendocrine functions …

Melatonin, the pineal gland hormone, is widely distributed in mammalian tissues and exerts
its action via two melatonin receptor sub-types, MT1 and MT2. Melatonin is known to play …

Melatonin is a neurohormone synthesized and secreted mainly during the dark period of the
circadian cycle by the pineal gland. It has already been proved to be involved in a number of …

Melatonin, an endogenous ligand for melatonin receptor, plays an important role in
modulating various physiological activities through acting on different subtypes MT1, MT2 or …

In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …

A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic
ligands. Modulation of affinity of the newly synthesized compound by applying SARs around …

Melatonin receptors are Class AG protein-coupled receptors (GPCRs) that regulate a
plethora of physiological activities in response to the rhythmic secretion of melatonin from …