New multi-target indole and naphthalene derivatives containing the oxadiazolone scaffold
as a bioisostere of the melatonin acetamido group have been developed. The novel …

The third melatonin binding site, MT3 is a non-classical one since it is not a seven
transmembrane domains receptor, but an enzyme, quinone reductase 2. A major concern for …

A three-dimensional quantitative structure− activity relationship using the comparative
molecular field analysis (CoMFA) paradigm applied to 57 melatonin receptor ligands …

Melatonin, or N-acetyl 5-methoxytryptamine, a neurohormone produced in the pineal gland
during periods of darkness, plays a key role in the regulation of circadian and seasonal …

In recent years, many physiological properties of melatonin have been described resulting in
much interest in the development of synthetic compounds possessing agonist or antagonist …

Melatonin, the neuro‐hormone synthesized during the night, has recently seen an
unexpected extension of its functional implications toward type 2 diabetes development …

3-(Acetylaminomethyl)-2-(ethoxycarbonyl)-6-methoxy-1, 3, 4, 5-tetrahydrobenzo [cd] indole
(2) is a rigid melatonin analogue that as a racemate displays about the same affinity and …

Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …

We report the synthesis, binding properties and intrinsic activity at MT1 and MT2 melatonin
receptors of new dimeric melatonin receptor ligands in which two units of the monomeric …

The melatonin receptor family is a small group of receptors within the G protein‐coupled
receptor (GPCR) superfamily. The group comprises of three subtypes which bind melatonin …