Benzofuranic analogues of MCA-NAT (5-methoxycarbonylamino-N-acetyltryptamine) have
been synthesized and evaluated as melatonin receptor ligands. Introduction of a …

Melatonin is a hormone mainly produced by the pineal gland and MT1 is one of the two G
protein-coupled receptors (GPCRs) mediating its action. Despite an increasing number of …

Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

Melatonin is a hormone exerting its multiple actions mainly through two G‐protein‐coupled
receptors MT1 and MT2. Exploring the physiological role of each of these subtypes requires …

Melatonin is an endogenous molecule involved in many pathophysiological processes. In
addition to the control of circadian rhythms, its antioxidant and neuroprotective properties …

Melatonin receptors have been studied for several decades. The low expression of the
receptors in tissues led the scientific community to find a substitute for the natural hormone …

Ever since the idea arose that melatonin might promote sleep and resynchronize circadian
rhythms, many research groups have centered their efforts on obtaining new melatonin …

The functional role of melatonin receptors in the mammalian central nervous system and
their therapeutic potential is discussed. Melatonin, dubbed the “hormone of darkness,” is …

A new series of melatonin (MLT) dimers were obtained by linking together two melatonin
units with a linear alkyl chain through the MLT acetamido group or through a C-2 …

Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …