Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts
its multiple roles mainly through two seven transmembrane domain, G-coupled receptors …

Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

A series of substituted N-[3-(3-methoxyphenyl) propyl] amides were synthesized and their
binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was …

Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …

The MT2‐selective melatonin receptor ligand UCM765 (N‐(2‐((3‐methoxyphenyl)(phenyl)
amino) ethyl) acetamide), showed interesting sleep inducing, analgesic and anxiolytic …

The linear regression (LR) and non-linear regression methods–grid search-support vector
machine (GS-SVM) and projection pursuit regression (PPR) were used to develop …

Introduction Major depressive disorders (MDD) pose major health burdens globally.
Currently available medications have their limitations due to serious adverse effects, long …

Background and Purpose The paradigm that GPCRs are able to prolong or initiate cellular
signalling through intracellular receptors recently emerged. Melatonin binds to G protein …

Focused small libraries of melatonin receptor ligands from arylalkylamine derivatives were
synthesised by combinatorial chemistry using the mix and split method in the solid phase. A …