Introduction Major depressive disorders (MDD) pose major health burdens globally.
Currently available medications have their limitations due to serious adverse effects, long …

Importance of the field: Melatonin is a major chronobiological regulator involved in circadian
phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune …

Tetrahydronaphthalenic analogues of melatonin have been synthesized and evaluated as
melatonin receptor ligands. Introduction of a phenyl substituent in the 3-position of the …

Focused small libraries of melatonin receptor ligands from arylalkylamine derivatives were
synthesised by combinatorial chemistry using the mix and split method in the solid phase. A …

Although melatonin is an astonishing molecule, it is possible that chemistry will help in the
discovery of new compounds derived from it that may exceed our expectations regarding …

Conformational analysis was used to characterize the agonist pharmacophore for melatonin
sheep brain receptor recognition and activation. The molecular geometry shared by all …

A series of substituted isoquinolinones were synthesized and their binding affinities and
functional activities towards human melatonin MT1 and MT2 receptors were evaluated …

A series of novel and selective N-[3-(6-benzyloxy-3-methoxyphenyl) propyl] amides has
recently been shown to possess sub-nanomolar range binding affinity to the type 2 …

Pineal hormone melatonin is widely used in the treatment of disorders of circadian rhythms.
The presence of melatonin receptors in various animal tissues motivates the use of this …

The class of N‐(anilinoethyl) amides includes melatonin receptor ligands with varied
subtype selectivity and intrinsic activity. One of these ligands, the MT2‐selective partial …